A Study of Super-High Speed Machining

This paper is concerned with the fundamental study of super-high speed machining. Cutting tests were performed on carbon steel with carbide, ceramic, and cermet tools to investigate the fundamental problems such as tool forces, tool life, surface roughness, etc. at super-high speeds (above the conventional cutting speed) obtained easily by the latest high-speed precision lathe, and to find out the possibility of practical use of super-high speed machining in machine shops. It was found that a certain grade of the ceramic tool has a great possibility of being used for super-high speed machining. Super-high speed machining operation produced an excellent surface finish, increasing the productivity of finish operation, but the tool life at super-high speeds was short at the present stage. The development of tool materials with high heat resistance and machine tools with high rigidity enough for super-high speeds is expected. Cutting fluids supplied to super-high speed machining increased surface finish slightly, but decreased tool life

A case of complete decapitation

Complete decapitation due to suicide by hanging is rare. We report the case of a decapitated man who was found in the sea near an estuary. A polyethylene rope was tied to the handrail of the bridge across a strait near the site of the body. The rope was 12 mm in diameter and 19 m in length from the handrail. It ended with a slip knot noose, and skin and mustache-like hair fragments were attached to it. The decapitated head was not found. The deceased weighed 82 kg and was 152 cm long without the head. The autopsy revealed coarse abrasions and intramuscular hemorrhage around the severed edge. The third cervical spine was not fractured. We reviewed the literature and suggested the conditions of body weight, fall height, rope diameter, and number of rolls in cases of decapitation by hanging. We calculated the hanging decapitation index (HDI) as the fall height (m) multiplied by the body weight (kg), divided by the rope diameter (mm), divided by the number of rolls ; and discussed the differences between complete and incomplete decapitation cases

Antidepressant-Like Activity of 10-Hydroxy-Trans-2-Decenoic Acid, a Unique Unsaturated Fatty Acid of Royal Jelly, in Stress-Inducible Depression-Like Mouse Model

Symptoms of depression and anxiety appeared in mice after they had been subjected to a combination of forced swimming for 15 min followed by being kept in cages that were sequentially subjected to leaning, drenching, and rotation within 1-2 days for a total of 3 weeks. The animals were then evaluated by the tail-suspension test, elevated plus-maze test, and open-field test at 1 day after the end of stress exposure. Using these experimental systems, we found that 10-hydroxy-trans-2-decenoic acid (HDEA), an unsaturated fatty acid unique to royal jelly (RJ), protected against the depression and anxiety when intraperitoneally administered once a day for 3 weeks simultaneously with the stress loading. Intraperitoneally administered RJ, a rich source of HDEA, was also protective against the depression, but RJ given by the oral route was less effective. Our present results demonstrate that HDEA and RJ, a natural source of it, were effective in ameliorating the stress-inducible symptoms of depression and anxiety

Regulatory Policy to Mitigate Potential Risks Arising from Contingent Convertibles

A Contingent Convertible (CoCo) bond is an instrument that converts into equity or suffers a write-down when the issuing bank is in financial distress. In practice, a trigger event of CoCo takes place when the capital ratio of the bank falls to the pre-defined level or when the national authority declares a trigger at its discretion. The aims of this study are to model CoCos having such triggers and to find effective regulatory policies to handle them. A model for banks issuing CoCos is built within the framework of a structural-default approach. The trigger mechanisms are expressed in a first passage time model and in a stochastic intensity model. CoCo investors are also included in our model as CoCos are designed to enhance the bank\u27s resilience while shifting its risks to the investors. In the numerical example, we show that effective regulatory policy, which is intended to mitigate both banks\u27 and investors\u27 default risks, changes according to the correlation between banks and investors and the impact of the trigger event on the bank asset value process.首都大学東京, 2018-03-25, 修士（経営学）首都大学東

Purification, crystallization and preliminary crystallographic characterization of the α2,6-sialyltransferase from Photobacterium sp. JT-ISH-224

Crystallization of the α2,6-sialyltransferase from Photobacterium

高等教育への障害者のアクセス:教育のユニバーサルデザイン : 米国の障害者支援システムに学ぶ

This paper has three purposes. First, it seeks to pursue a support system for persons with disabilities seeking higher education in the USA and to present the idea of "Universal Design in Education." Second, we will discuss the support system in the University of Oregon as a practical case in point. Finally, we will examine the access given to people with disabilities to higher education in Japan. The study incorporates literature, conference documents, internet searches, and an on-site inspection. The results were as follows. 1. In US facilities of higher education, disabled students receive various special services under the law. 2. Under the idea of "Universal Design in Education," it was practicable for students with learning disabilities to access higher education. 3. The practical experiments in the United States provide suggestions for application in Japan

「ろう文化」をアイデンティティとする学生を含む卒論演習の実践報告 : 「社会政策演習」2セメスター30回の記録を用いて

In 2005, the Department of Social Work and Environmental Sciences of Showa Women\u27s University accepted its first deaf student, A. The student, A, who identifies as a member of "Deaf Culture" wrote a graduation thesis as a member of the "Social Policy Seminar." She did so with the assistance of the supervising professor and a doctoral candidate in Showa\u27s graduate school who served as a teaching assistant. With the aid of seven seminar students who were members of the sign language circle the researchers analyzed the records of 30 exercises spanning two semesters. This report will first show the process how communication with the deaf student was made possible. Second, it will explain how intercultural understanding was achieved between the culture of the deaf and the culture of the hearing

The Outcome of Cochlear Implantation for Mitochondrial Disease Patients With Syndromic Hearing Loss.

【Objectives】To evaluate the outcome and to confirm the validity of cochlear implantation for syndromic deafness in patients with mitochondrial disease. Study Design: Retrospective case review. 【Setting】Tertiary referral center. 【Patients】We reviewed medical charts of 367 cochlear implantation cases at Kyoto University Hospital between 1987 and 2012. We identified five patients with syndromic mitochondrial disease who underwent cochlear implantation surgery. The mean age of the patients (four women and one man) when they underwent surgeries was 44.4 years (range, 30–64 yr; median, 41 yr). 【Interventions】Therapeutic and rehabilitative. 【Main Outcome Measure】In four of five patients, speech perception performance was measured using Japanese vowels, consonant-vowel syllables, and short sentences. 【Results】Only 1.4% (5 of 367) of cochlear implantation cases at Kyoto University Hospital underwent cochlear implantation surgery because of syndromic mitochondrial diseases. Four of those patients showed significantly improved speech perception outcomes, and the beneficial effects of the intervention continued long after surgery. One patient could not perform speech perception test presumably because of poor cognitive function. 【Conclusion】Mitochondrial disease patients who underwent cochlear implantation surgery sustained gains in hearing performance even long after surgery. A single patient showed poor postoperative speech perception associated with cognitive problems. Cochlear implantation for mitochondrial disease patients seems to be a viable treatment option in the absence of significant cognitive impairment

The efficacy of skin care products containing glutathione in delivering skin lightening in Indonesian women

Glutathione is a potent antioxidant, which is widely used in skin care products for skin lightening especially in the Asian market. Presently, there was only one study of topical 2% oxidized glutathione (GSSG) in Philipino women, further study is needed to evaluate the efficacy and safety of cosmetic products containing glutathione. A double blind randomized clinical trial study was conducted in Yogyakarta, Indonesia, in 74 healthy Indonesian women, with average age 33.3 ± 5.9 years when subjects participated in the study. Each subject received supervised applications of Facial Wash twice a day, Day Cream with sunscreen and Night Cream. The subjects were divided into 3 groups based on the active ingredients of the tested products, which included glutathione reduced (GSH) 0.1%, GSH 0.5%, and without GSH. The effects of the tested products in lightening skin color and pigmentation were measured colorimetry with Chromameter Minolta for L*. Compared to a baseline, there were significant increases of L* (lightness) or ΔL* detected as early as week 2 in which group of GSH 0.1% were significantly higher compared to group of GSH 0.5% and group without GSH. Hyperpigmented lesions also improved, where GSH 0.5% group showed its superiority compared to others groups in week 8. The undesired effect were few minutes mild tingling sensation after night cream, and worsening of acne in all tested products. Conclusion skin care products containing GSH 0.1% and 0.5% were effective in facial skin lightening